Chemical Toxicology: A Chemist's Roadmap to Reduce Bioactivation Liabilities in Drug Candidates

This one-day short course run in conjunction with the Medicinal Chemistry Symposium will increase your overall knowledge of mechanisms of drug metabolism mediated toxicity.

Who Should Attend:

Medicinal chemists, drug metabolism scientists and other scientists interested in learning more about the background of mechanistic drug metabolism mediated toxicology and how to apply these learnings to drug discovery and development

Key Topics You'll Learn About:

• Mechanisms of bioactivation
• Enzyme systems involved in bioactivation
• Methods for screening for reactive metabolite formation
• Mechanisms leading to metabolism-mediated toxicity
• Covalent binding & relevance to toxicity
• Case studies of structural optimization to reduce the risk of metabolism-mediated toxicity.

How You'll Benefit from This Course:

• Understand and gain confidence in the field of metabolism-mediated toxicology
• Be able to better recognize structures with the potential for bioactivation
• See how others have utilized reactive metabolite data and redesigned molecules to avoid the liability of bioactivation
• Become familiar with existing and new in vitro and in vivo techniques for identifying risks of chemically mediated toxicology.

Course Topics:

• Introduction to drug metabolism and mechanisms of bioactivation
• Overview of the enzymes important in bioactivation, important species and inter-subject differences in enzyme expression
• Methods for investigation of reactive metabolites as part of drug discovery programs; case studies of optimization of molecular structure to reduce risk of toxicity
• Mechanisms leading to metabolism-mediated toxicity
• Strategies useful for evaluation of reactive intermediates as part of a candidate optimization program
• Covalent binding & relevance to toxicity

The Instructors:

The course will be taught by a small group of academic and industry leaders in the field of metabolism-mediated toxicology:

• F. Peter Guengerich, Center in Molecular Toxicology, Vanderbilt University
• Kaushik Mitra, Department of Drug Metabolism, Merck Research Laboratories
• Griff Humphreys, Department of Biotransformation, Bristol-Myers Squibb

Short Course Registration Policies

Fees

Fee/Payment Information

Course fees include tuition, course binder and a continental breakfast. Fees do not include hotel rooms. Prepayment is required to confirm your registration. Registration can be accomplished with a credit card via the Med Chem Symposium website using the following link: http://register.cce.umn.edu/Course.pl?sect_key=184026

Registration Deadline

Although there is no deadline for registering, we urge everyone to enroll as early as possible. If it is less that two weeks before the start of a course, please call 609-252-3636 to that confirm space is available.

Cancellation Policy

Anyone who has registered for a short course, but cannot attend, should call our office immediately. To receive a refund, minus a $50 administration fee, registrants must call at least 10 business days before the start of the course. An alternate may also be appointed to attend the course up to the last minute. In the event of instructor illness or low enrollment this course may be cancelled. Registrants of cancelled courses will be notified as soon as the decision has been made and refunded in full.